产品货号：
Z10280
中文名称：
ADAM17抗体
英文名称：
Anti-ADAM17 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ADAM17 Antibody |
| 指标别名 | ADAM 17;ADAM17;CD156b;cSVP;Snake venom like protease;TACE;TNF alpha convertase;TNF alpha converting enzyme |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | ADAM17 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human ADAM17(806-824aa AASFKLQRQNRVDSKETEC),different from the related rat and mouse sequences by one amino acid. |
| 实际分子量 | 93KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | ADAM17(ADAM metallopeptidase domain 17),also called TACE (tumor necrosis factor-alpha-converting enzyme),is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases.Expression studies showed that the encoded protein cleaves precursor tumor necrosis factor-alpha to its mature form.Northern blot analysis revealed that the gene was expressed as a 5-kb mRNA in all tissues examined.ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha(TNF-alpha) at the surface of the°Cell,and from within theintracellular membranes of the trans-Golgi network.This process,which is also known as "shedding",involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins(such as pro-TNF-alpha),and is of known physiological importance.ADAM17 was the first "sheddase" to be identified,and is also understood to play a role in the release of a diverse variety of membrane-anchored°Cytokines,°Cell adhesion molecules,receptors,ligands,and enzymes. |
| Uniprot ID | P78536 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | ADAM metallopeptidase domain 17 |
| 蛋白名全称 | Disintegrin and metalloproteinase domain-containing protein 17(ADAM 17) |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
相关搜索：ADAM17抗体，ADAM17多抗，Anti-ADAM17 Antibody